Mitochondrial Genetic Background Modifies Breast Cancer Risk

Mitochondrial genetic background modifies breast cancer risk.

Inefficient mitochondrial electron transport chain (ETC) function has been implicated in the vicious cycle of reactive oxygen species (ROS) production that may predispose an individual to late onset diseases, such as diabetes, hypertension, and cancer. Mitochondrial DNA (mtDNA) variations may affect the efficiency of ETC and ROS production, thus contributing to cancer risk. To test this hypothe...

Genetic polymorphism in ERCC5 and breast cancer risk

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

Genetic polymorphism in ERCC5 and breast cancer risk

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

[Genetic risk of breast and ovarian cancer].

Genetic insights into breast cancer risk

Since the identification of BRCA1 and BRCA2 much has been learned about the role of mutations in these genes and how they relate to disease risk. The primary population that has been screened for mutations in these genes has been women who have a family history of early onset breast and or ovarian cancer. The tumour characteristics of women who harbour a BRCA1 mutation are similar to those iden...